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Glutamine, regulated by c-MYC, is facilitated by type 2 amino acid transport protein (ASCT2) and sodium-coupled neutral amino acid transport protein 5 (SN2) to cross the cell membrane, enter the cytoplasm, and be converted into glutamate by glutaminase (GLS/GLS2)
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29 Previous studies had shown that RBC from G6PD deficient donors (the most common enzymopathy in humans, affecting ~10% of the donor population in some metropolitan areas 26 ) are naturally incapable of coping with oxidant stress owing to the ablation of the NADPHgenerating PPP
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