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As a result, sAC deficiency in mice was shown to result in male sterility because of sperm motility and capacitation defects, precluding sperm migration to the fertilization site (for reviews, see refs
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The chemotherapy drug, 5-fluorouracil (5-fu), inhibits TS activity by disrupting action of TS, causing DNA and RNA damage, making 5-fu an effective and commonly used cancer treatment [74]
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