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An open-label biomarker study of EMA401 was conducted in a phase II clinical trial of OIPN patients to prove the conceptual use of EMA401 in OIPN
inhalation therapy
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This could be traced back to the fact that GSTO1 is not under Nrf2/ARE control [271]: it acts more like glutaredoxins than GSTs [272] and is involved in the activation of inflammasome [273]
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