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Furthermore, the intricate crosstalk between PCa cells and stromal cells, including Cancer-associated fibroblasts (CAFs), endothelial cells, and adipose stromal cells (ASCs), contributes to the progression of PCa (Heidegger et al., 2022)

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Four possible factors mainly induce this process: massive release of the iron homeostasis regulator Hepcidin, excessive iron influx dependent on the transferrin receptor (TfR), which mediates cellular iron uptake through endocytosis of iron-loaded transferrin during SARS-CoV-2 replication, attack of hemoglobin to release free iron into the circulation, and inhibition of GPX4 by SARS-CoV-2 (107–109)