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Despite the necessity of Rheb in mTORC1 activation, the mechanistic details of how Rheb-GTP activates mTORC1 remain controversial, although the strongest evidence supports activation through direct interaction (Long et al., 2005a
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The findings demonstrated that the levels of IL-1Ξ± (9.9% Β± 3.7, p = 0.013) and IL-6 (26.5% Β± 8.2, p = 0.003) were only significantly reduced in the (+) ALA/GLA group
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