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Additionally, the proposed methodology aligns with the benchmarking methodology used for cost measures, which are also administrative claims-based measures and automatically calculated by CMS

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(Travis et al., 2015) Fusion gene strategies can be employed to co-express helper epitopes or cytokines (e.g., GM-CSF, IL-12) along with tumor antigens, thereby promoting T-helper memory cell differentiation and sustaining long-term immune responses (van der Burg et al., 2016)