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In fact, both incidence and prevalence of psychiatric disorders (including BD) are higher in IBD patients [103]
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Other examples include the recently reported ability of nuclear IGF-1R to drive chemotherapy resistance in various types of cancer, and notably, through interactions with nuclear mitotic apparatus (NuMA) protein and regulating p53−binding protein 1 (53BP1) −dependent DNA double−strand break repair in colorectal cancer ( in vitro (42)
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