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Keywords: nicotinamide N-methyltransferase (NNMT), metabolic syndrome (MetS), nicotinamide adenine dinucleotide (NAD + ), homocysteine (Hcy), obesity, diabetes, hyperlipidemia, hypertension 1 Introduction Metabolic syndrome (MetS) constitutes a multifaceted array of metabolic disorders, manifesting as disturbances in the body’s handling of energy substrates, including proteins, fats, and carbohydrates