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LSD2 may function similarly, as when overexpressed, it upregulates NANOG, SOX2, LSD1, KDM4B, and KDM5B mRNA expression, promoting CSC-like characteristics and drug resistance [301]
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The specific timeline of derm irAEs could explain why this is not the case for gastrointestinal or endocrine toxicities, as they tend to appear within the first 3 months
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