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Introduction Iron metabolism Iron, which has the highest content of all essential trace elements in the human body, plays a critical role as a biologically essential component of every living organism ( via the production of reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (·HO), superoxide anions (O 2 − ), and other reaction intermediates with free radical properties ( 2 O 2 in it, thereby generating extremely reactive ·HO