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2 Effects of metformin on PCOS PCOS is a common disorder of hormonal and metabolic imbalance, characterized by hyperandrogenism, dysfunctional ovulation, and polyfollicular ovaries and accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity (Zhao et al., 2023), affecting women during their reproductive years, with potential long-term cardiovascular, metabolic, and reproductive health outcomes (Zhu et al., 2022
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