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The SELECT trial, enrolling over 17,000 patients with established cardiovascular disease over nearly 40 months, confirmed the cardiovascular safety of semaglutide and demonstrated net benefit in a high-risk population
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In fact, they showed an early increase in both mRNA and protein expression of the two subunits of GCL (GCLC) and (GCLM), and also of GS from day 1 to day 7 after BDL, but these indices decrease below the baseline by day 14 to day 28 after BDL [188]
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