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A behavioural study of the effect of pentadecapeptide BPC-157 in Parkinson’s disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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Even during the preparation and dissolution process of nanosuspension, insoluble precipitates are formed due to the intermolecular electrostatic interactions between partially ionizable anionic drugs and oppositely charged surfactants, which lead to the low drug content, increased particle size, the formation of rough and irregular crystals, and decreased dissolution [59]