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Since there is a high genetic heterogeneity in the Mexican population and a clear European ancestry gradient North-South in MEZ [18, 21, 22, 23], both MA and MEZ populations were sorted into five geographic regions, modified from those regions described in the Mexican Official National Journal and taking into consideration previously published genetic data: North (N), Central East (CE), Central West (CW), South (S), and South East (SE)[18]