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Sodium is imported into cells through some cellular metal ion transporters coupled to various ion channels, including the voltage-gated sodium channel (VGSC), the epithelial sodium channel (ENaC), the acid-sensing ion channel (ASIC), the N -methyl-d-aspartate receptor (NMDAR), the purinergic P2X receptor 7 (P2X7R), and the sodium leak channel nonselective (NALCN), which are differentially expressed in distinct tissues 46,47 and of which ENaC is the most well-characterized to date 48 (Figure 4)

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