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AMPK is closely related to mitochondrial autophagy, 97 which maintains mitochondrial function under stress by timely clearing of damaged mitochondria
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In fact, analgesic and anti-inflammatory effects produced by many phytochemicals are considered to occur via Nrf2 pathway (Kumar et al., 2014), secondary to increased phase 2 enzymes, GSH production and turnover [GCL and glutathione reductase (GR)], increase of HO-1 and NQO1 levels, and reduced ROS levels (Ma, 2013