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The degradation and destruction of cartilage ECM leads to increased irregularity and wear of the articular surfaces, which in turn causes destruction and remodeling of the bone microarchitecture

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Giacalone JC, Sharma TP, Burnight ER, Fingert JF, Mullins RF, Stone EM, et al