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pointed out that renal hypoxia contributes to heightened T cell infiltration and kidney damage, partially mediated by HIF-1α-induced metabolic reprogramming in lupus-prone mice (MRL/lpr mice)

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Nevertheless, Tecfidera's trials showed side effects like leucopenia and significant gastrointestinal problems, while Omaveloxolone has very common side effects, over 10%, including elevated liver enzymes (AST/ALT), headache, etc