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In rodents, these approaches include, among others, genetic alterations/mutations ( e.g., α-synuclein mutation), infusion of neurotoxins ( e.g., 6-hydroxydopamine – 6-OHDA, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–MPTP), and administration of pharmacological agents ( e.g ., reserpine)