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In particular, the metabolism of cellular metal ions, such as iron and copper, regulates ROS production and mitochondrial biogenesis [12, 14, 52, 53]

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MDA determination A 0.2 ml sample or standard was mixed well with 1 mL of 25 mM/L chromogen (thiobarbituric acid), covered, and heated in a boiling water bath for 30 min

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