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In a phase 2 trial of participants with overweight/obesity and T2D, CagriSema induced a mean 15.6% reduction in baseline weight at 32 weeks (Figure 2) (89)

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Mechanistically, BPC-157 activates VEGFR2 via the PI3K-Akt-eNOS axis to promote angiogenesis, stimulates ERK1/2 signalling to enhance fibroblast proliferation and migration, and modulates the NO system to regulate vascular tone