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Aged wild-type mice (PPARα +/+ ) treated with both DHEA (chow containing 0.5% DHEA or 25 mg/day) and DHEAS (100 µg/ml in drinking water) had lower tissue lipid peroxidation, decreased NF-κB activity in the spleen, and lower pro-inflammatory cytokine production compared to homozygous knockout (PPARα −/− ) mice treated with both DHEA and DHEAS, suggesting that DHEA(S)’ influences on these effects are mediated through PPARα [244]

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These studies show that the phenolic acid bioactive metabolites in L