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Increased levels of fission genes (e.g., Drp1 and Fis1) and decreased levels of fusion genes (e.g., OPA1, Mfn1, and Mfn2) promote mitochondrial fragmentation and ROS overproduction [110, 111]
1 LR3 protein has been specifically engineered for higher biological potency and is used in the maintenance of human pluripotent stem cells.
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