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The novel SIRT1 activator SRT2104 may offer protection against diabetic nephropathy by modulating the SIRT1/P53/NRF2 axis, thereby enhancing renal antioxidant activity in diabetic conditions [69]
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Rec Nat Prod 5:158–175 [Google Scholar] Gulcin I, Beydemir S, Topal F, Gagua N, Bakuridze A, Bayram R, Gepdiremen A (2012) Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst