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To determine whether the improved cognitive function resulting from HDAC9 overexpression is associated with improved synaptic plasticity, a separate cohort of 5xFAD and 5xFAD/HDAC9-Tg flox-STOP-flox mice received tail vein injections of either AAV-PHP.eB-GFP-Cre or the control AAV-PHP.eB-GFP
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