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Knatko, Higgins, Fahey, & Dinkova-Kostova (2016) found that the incidence, multiplicity and burden of squamous cell carcinomas that form when Nrf2 is knocked out in KEAP1 knockdown mice [ Keap1(flox/flox)/Nrf2 (−/−)] are much greater than in their Keap1(flox/flox)/Nrf2( +/+ ) counterparts, establishing NRF2 activation as the protection mediator
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