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Contrarily, “controlling of angiogenesis” is along with an increased angiogenesis to promote healing, 73 an increased expression of vascular endothelial growth factor (VEGF) and subsequent pathways, 2 , 96 - 101 and as study of Kang et al., 2 documented, BPC 157 fully counteracted tumor cachexia, and prolonged survival, counteracted increase of the pro-cachectic and pro-inflammatory cytokines, and related molecular pathways effects

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392,393 To date, many key regulatory molecules exerting dual roles in regulating DNA repair and cellular metabolism have been identified, including p53, 394 sirtuins, 395,396 poly(ADP-ribose) polymerases (PARPs), 397 and ATM