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Treatment with apigenin induced apoptosis, suppressed glycogen synthase kinase-3 (GSK-3)/NF-κB, and downregulated Bcl-xL, CCL2, CXCL-8, IL1A, Bcl-2, and VEGF in pancreatic (PANC-1 and BxPC-3) (147), prostate (PC-3) (148, 149), and breast (MDA-MB-231) cancer cells (150), as well as the athymic nu/nu nude (151) and TRAMP mice (152) cancer models
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