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Patients who had been on stable, physician-supervised peptide regimens lost access to compounds that had no FDA-approved equivalent

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Of note, lysine methyltransferases (KMTs) have higher Km values for SAM than protein arginine methyltransferases (PRMTs), hence the overall lysine methylation levels on H3 are easier to be reduced when SAM/SAH ratio fluctuates under the condition of cofactor competition by NNMT [55]