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Superoxide dismutases (SODs) and catalase (CAT) are the major endogenous antioxidant defense systems against ROS (Racchi, 2013
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Chronic exposure to GCs elevates the protein expression of nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 1 (NLRP-1), Caspase-1, Caspase-5, apoptosis associated speck-like protein (ASC), nuclear factor-jB (NF-jB), p-NF-jB, interleukin-1b (IL-1b), IL-18, IL-6, and microtubule associated protein 2 (MAP2) in the frontal cortex and hippocampus of male mice, suggesting GCs/NLRP-1 inflammasome-mediated neurodegeneration (Wilhelm et al., 2015)
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