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Ferulic acid-chitosan nanoparticles (FA-ChNPs) act as a multimodal radiosensitizer through three synergistic mechanisms: enhancing radiation-induced DNA damage by suppressing cytokine-mediated survival signaling and reprogramming the tumor immune microenvironment through dual cytokine modulation-downregulating radioresistance-associated cytokines while upregulating radiosensitizing cytokines 20,21,22
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