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Both of these mutations are in strong linkage disequilibrium and create a two-allele risk haplotype, which increases the odds of acquiring Crohn’s disease 1.5- to 12-fold (56)

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Nrf-2 is a transcription factor essential in HepG2 cells for the ARE-mediated induction of phase II detoxifying and γ-glutamate-cysteine ligase genes in response to ROS, electrophiles and phenolic oxidants [98]