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290 Both the α2-adrenergic agonist dexmedetomidine and the tricyclic antidepressant amitriptyline have been found to improve UC by inhibiting TLR4

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Both paracellular hyperpermeability [demonstrated by abnormal TJ expression and upregulation of myosin light chain kinase (MLCK) activity (322–324)] and transcellular hyperpermeability [represented by bacterial internalization to epithelia (325)] were documented in mucosal biopsies of patients with Crohn's disease and UC