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Pyridoxine has a history of successful use, at doses ranging from 50 to 800 mg per day, for the prevention and treatment of HFS caused by sorafenib (Nexavar), doxorubicin, 5-FU, docetaxel, or etoposide
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k obs was then plotted against the inhibitor concentrations and fitted to the equation (3) y = k inact /(1+( K i / x )) for k inact and K i