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These cells secrete pro-inflammatory cytokines such as interferon-gamma (IFN-γ), interleukin-1 beta (IL-1β), and interleukin-17 (IL-17), which stimulate the activation and proliferation of orbital fibroblasts and adipocytes ( in vitro model of TGF-β-induced orbital fibroblast activation, inhibition of TGF-β reduced levels of α-SMA, type I collagen, Timp-1, and vimentin, and decreased TGF-β-induced phosphorylation of ERK, p38, JNK, and NF-κB ( Ferroptosis, characterized by disruptions in redox homeostasis and increased lipid peroxidation, can stimulate inflammatory cells and pathways, leading to pro-inflammatory cytokine production that, in turn, intensifies intracellular oxidative stress and further promotes lipid peroxidation ( IFN-γ is a critical cytokine in host immunity against tumors, enhancing the susceptibility of tumor cells to ferroptosis through the JAK-STAT signaling pathway ( in vivo macular degeneration ( Similarly, the activation of inflammation through the MAPK pathway is pivotal in triggering ferroptosis ( 2.4 Ferroptosis and fibrosis in TAO The intricate interplay of tissue expansion, remodeling, and fibrosis in TAO significantly contributes to the onset and progression of the disease ( + and CD8 + T cells, mast cells, and B cells, into orbital tissue

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Probiotics can help support a healthy gut microbiota Next, let’s talk about the six supplements that can help you reduce inflammation, replenish depleted nutrients, and help gut imbalances