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Performing motif discovery analysis using HOMER 17 , we found that resolved-accessible DARs are highly enriched for transcription factor (TF) binding motifs of the AP-1 family members, which are known mediators of stress responses, often downstream of cytokine signalling (Extended Data Fig
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345,346 In gastric cancer cells, DLAT expression is notably upregulated, enhancing oxidative phosphorylation by catalyzing the conversion of pyruvate to acetyl-CoA, thereby supplying energy to tumor cells
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