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5.2 Exercise regulates oxidative stress As a principal driver of ferroptosis, oxidative stress is defined as a physiological or pathological condition wherein the production of ROS and reactive nitrogen species (RNS) under endogenous or exogenous stimuli surpasses the neutralising capacity of the antioxidant defence system, thereby causing oxidative damage (Islam, 2017)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Greenberg B., Butler J., Felker G.M., Ponikowski P., Voors A.A., Pogoda J.M., Provost R., Guerrero J., Hajjar R.J., Zsebo K.M