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Methods This narrative review was performed utilizing targeted literature search of PubMed, MEDLINE, and Google Scholar searches and recent high-impact reviews.38,39 We began our narrative review by reviewing the included references and searching the above registries with pertinent keywords including obesity, pharmacotherapy, phentermine, naltrexone, bupropion, topiramate, GLP-1, bariatric, anti-obesity, weight loss, and nutrition among others
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Furthermore, flies harboring a global null mutation of Ube3a exhibited significant circadian deficits, supporting the notion that Ube3a is an integral component of the Drosophila circadian clock (Wu et al., 2008)