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Moreover, the non-coding RNA miR-107, which is down-regulated in several CRC cell lines (LoVo, SW480, HT29, DLD-1, SW620) and in patient CRC tissue, was proposed to negatively regulate TfR1 expression, affecting the proliferation, invasion, and migration of CRC cells [87]

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Considering the diverse characteristics of the different trials, including differences in the selection and number of participants, dosage and duration of supplementation, as well as form of the supplements, further studies with more power, better standardization, and more complex design have to be conducted to unravel the role of the interrelation between vitamin E and other micronutrients for human health