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Cell death induced by cisplatin is concentration dependent and includes necrosis and apoptosis mechanisms (Gonzalez et al., Cisplatin distorts the structure of the DNA that generate intrastrand 1, 2—crosslinks binding proteins into shallow minor groove [high-mobility group (HMG) box proteins, repair proteins, transcription factors, histone H1] (Kartalou and Essigmann, 2002
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