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In 3–5% of cases, single-gene mutations are responsible, while others correlate with genetic risk variants, family history, constipation, nonsmoking status, and exposure to environmental toxins (e.g., pesticides and trichloroethylene) (149)
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In rats subjected to experimental hypoxia, a significant stress-mediated reduction in both the rate of phosphorylated respiration (V3, a 20% decrease) and the rate of ADP phosphorylation (ADP/t, a 31% decrease) was observed in brain mitochondria