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98 DYRK1A was demonstrated to phosphorylate APP on Thr-668, which then facilitated the BACE1-mediated cleavage of APP, leading to an increase of Aβ

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Results Systemic GDF11 administration restores memory decline and attenuates the depression-like phenotype We treated 22-month-old C57BL/6JRj male mice with rGDF11 via daily intraperitoneal (i.p.) injections at a dose of 1 mg kg −1 , as previously described 24