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Data collection All Participants underwent a complete ophthalmological examination including visual acuity assessment by Snellen chart, refraction using autorefractometer, slit-lamp examination, Goldmann applanation tonometry, dilated stereoscopic fundus examination using indirect ophthalmoscope for clinical determination of grade of retinopathy, peripapillary retinal nerve fiber layer thickness (RNFLT) and macular thickness measurements using 3D-2000 Spectral Domain optical coherence tomography OCT that uses 360-degree circular scan with 3.4 mm diameter centered on optic disc to measure RNFLT in four quadrants (inferior, superior, nasal and temporal) and line scan for macula measuring inner and outer macular thickness in four quadrants (inferior, superior, nasal, and temporal)

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Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF-κB axis both in vitro and in vivo