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This deficiency is associated with 5-oxoprolinuria along with chronic acidosis, anemia, and central nervous system damage, and although rare, was one of the most commonly recognized causes of pyroglutamic metabolic acidosis [13] until 1989 when an acquired deficiency was first described in an adult [15]
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NAD+ works through mitochondrial restoration and DNA repair: it addresses systemic energy, cellular aging, and the biological substrate that supports mental and physical performance over weeks