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Among antiapoptotic changes, including decreasing p53, decreasing caspase 3 and increasing bcl-2/bcl-x or bax, most drugs induce more than one effect ( Figure 4 )

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This may due to that, the formation of programmed DNA double-strand breaks (DSBs) occurs at leptotene and zygotene during meiosis and is repaired by homologous recombination before late pachytene [30, 49, 50]