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This enzyme also produces smaller amounts of monohydroxylated metabolites 9( Z ),12( Z )-8-HODE and 10-HODE, and it has also been shown to oxidize the 8- and 10-position of ALA and OA, but not of GLA, which is a poor substrate

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CKD-MBD occurs in nearly every patient with stage 5 CKD (eGFR 14 grams) decreased the effectiveness of ACE inhibitor therapy and increased the risk for kidney failure