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As expected, the CTCF ZF4-7 H373R exhibited major deficits in its ability to recognize the CTCF consensus motif, whereas in contrast, the H373R mutant showed no defects in G4 recognition ( Fig.2H-J )

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Kirscher-Hermans et al., in 2019, reviewed four randomized, placebo-controlled clinical trials that examined the efficacy of a promising herbal preparation (called WS PRO 160/120 available in Germany) for the treatment of patients with LUTS/BPH related symptoms [186]