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TGF-β receptor type 1 is a negative regulatory mediator of liver fibrosis primarily because of its capacity to drive the COOH-terminal phosphorylation of Smad3 (pSmad3C) and upregulation of p21 transcriptional activity (166)

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When a corticosteroid is injected, inflammation and swelling are reduced, which relieves pressure on the nerves and other structures in your spine