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Cu has the capacity to directly bind to and stimulate epidermal growth factor receptor (EGFR) and mesenchymal to epithelial transition factor (MET) signaling even in the absence of their respective ligands, epidermal growth factor (EGF) and hepatocyte growth factor (HGF) [50]

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25 An altered gut microbiota may modify the production of various neurotransmitters and neuromodulators, affecting the functioning of the skin barrier and immune system, two key parameters of the pathophysiology of atopic dermatitis

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