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Alternatively, peptide bond surrogates can have protease inhibitor activity at the substrate cleavage site, and therefore offer a fundamental strategy for understanding protease enzyme activity, especially if isosteres can imitate the transition state of bond degradation (hydrolysis)
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In the absence of validated protein, metabolite or genetic markers in CSF or blood, identifying patients most likely to benefit from ferroptosis-targeting therapies, assessing the treatment response or dose adjustment are difficult (9)